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pentobarbital will lessen the extent or result of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Pitolisant exposure is decreased by fifty% if coadministered with potent CYP3A4 inducers.pentobarbital will minimize the extent or influence of roflumilast by impacting hepatic/intestinal en